The discovery of topological states and topological phase transitions has reshaped our understanding of physics and materials over the past few years. The topological transition from a normal insulator to a topological insulator (TI) can be realized by chemical or mechanical pressure. The topological transition was first predicted and demonstrated in Tl-based chalcogenides TlBi(S1−xSex)2 by i...

In November, Life Dean's Lecture of ShanghaiTech came again as scheduled. The Life Dean's Lecture is a special edition of the SLST Seminar held once a year, where distinguished experts in life sciences are invited to share the frontier scientific advances with faculty and students. This year, James Rothman, winner of the 2013 Nobel Prize in Physiology or Medicine and Distinguished Adjunct ...

Synthetic Lethality (SL) is a type of genetic interaction in which the simultaneous inactivation of two genes leads to cell death, while the inactivation of one gene alone does not affect the viability of the cell. In a pair of SL genes, if one gene has a cancer-specific mutation, the other gene can be a potential drug target because perturbation of the latter gene can selectively kill cancer cell...

As an important small molecule metabolite, NAD+ is widely involved in a series of biochemical reactions in cell energy metabolism, such as glycolysis, oxidative phosphorylation, and fatty acid oxidation. Tumor cells proliferate faster and are prone to DNA damage, requiring more NAD+ consumption. NAMPT is a key rate-limiting enzyme for NAD+ synthesis. Aberrant overexpression of NAMPT...

On October 28, ShanghaiTech won the gold medal in the 2022 International Genetically Engineered Machine Competition (iGEM) global finals among 350 teams from around the world. It is ShanghaiTech’s  sixth gold medal in this global student competition since its participation in 2016. The winning project is called “Mini Bioproduction Circle System on Mars Base (MBCS-Mars)”, conducte...

The two-day 2022 Head of Shanghai River Regatta was just concluded last weekend. The ShanghaiTech Boat Club participated in the 4.2-kilometer chase and 500-meter city dash of the regatta. In the men’s 4.2 km chase, ShanghaiTech team placed third and won the bronze medal with a time of 17 minutes and 23 seconds, the best result since ShanghaiTech’s first participation in the regatta. In the mixed...

Organic π-conjugated molecules (OCMs) have become promising candidates in the fields of organic catalysts, bio-imaging/sensing, and organic optoelectronics. Recently, introducing main-group elements (such as B, N, S, Si, P, etc.) into molecular backbones has become a powerful strategy for fine-tuning photo-physics, redox characteristics, molecular organizations, and optoelectronic functionalities...

On October 24, 2022, Dr. Philippe Roesle, CEO and Consul of Swissnex in China, Switzerland’s Science Consulate in Shanghai, visited ShanghaiTech University. Vice President Jiang Ge held a meeting with him.After extending a warm welcome to Philippe Roesle and his delegation, Jiang Ge briefed the internationalization strategy of ShanghaiTech and mutual visits and joint events with Swiss institution...

The great advances in deep learning techniques bring us a large number of sophisticated models that approach human-level performance in tasks such as image classification, speech recognition, and natural language processing. Despite its success, deep neural network (DNN) models are still vulnerable to adversarial attacks. Even with adding human-unrecognizable perturbations, the predictions of the ...

From October 3 to 6, the 13th China Undergraduate Physics Tournament (CUPT) was held online. ShanghaiTech team, consisting of 12 second-year undergraduates majoring physics, ranked ninth among 65 teams representing universities all over the country, and was awarded the First Prize, which was the best result since ShanghaiTech’s first participation in CUPT in 2019. ShanghaiTech team...

On September 30, Shanghai Clinical Research and Trial Center (SCRTC) managed by ShanghaiTech broke ground in Zhangjiang. This construction underway is the first phase of SCRTC, with 500 hospital beds planned, including 200 beds for clinical treatment and 300 for research, and the diseases under focus are tumors and those in the nervous, pan-vascular, respiratory, rheumatic, musculoskeletal as well...

Rich and tunable physical properties could emerge from the moiré superlattice constructed from two-dimensional multilayers. The magic-angle twisted bilayer graphene (MATBG) is one of the most distinguished examples, which exhibits unconventional superconductivity, correlated physics, ferromagnetism, and nontrivial topology far beyond monolayer graphene. Recently, magic-angle twisted trilayer grap...

A new study has been reported by the laboratory of Associate Professor Li Xiajun at SLST, ShanghaiTech, to elucidate maintenance of DNA methylation in embryonic stem cells. This paper entitled “DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells” is published in iScience, a Cell press journal, on September 16, 2022. DNA methylation is th...

The taste sensory system is responsible for examining food nutrition and avoiding ingestion of harmful substances. In humans, the tastants evoke five distinct taste sensations: sweet, bitter, salty, sour and umami. Interestingly, ion channels transduce the sour and salty signals, whereas, sweet, umami and bitter taste are mediated by G protein-coupled receptors (GPCRs). Among the five ta...