Topic: cGAS-STING signaling in diseases
Speaker: Professor Xu Pinglong, Life Science Institute, Zhejiang University (ZJU)
Date and time: 13:30–15:00, March 28
Venue: Auditorium of L Building
Host: Xi Ying
Abstract:
Dr. Xu’s lab employs multidisciplinary approaches to systematically elucidate the signaling mechanisms, biological functions, disease implications, and intervention strategies of nucleic acid sensing, an innate immune system. Dr. Xu identified the cGAS-STING-PERK signaling pathway, proposed that nucleic acid sensing activation is a universal mechanism leading to lysosomal storage disorders, discovered biological functions of nucleic acid sensing related to protein synthesis, neuronal loss, liquid-liquid phase separation, mitochondrial dynamics, and cellular transdifferentiation, and revealed key mechanisms by which nucleic acid sensing induces cellular senescence and fibrosis in the lungs, kidneys, and liver, and advanced theories on how oncogenes, blood glucose levels, nutritional microenvironments, and phase separation control innate immune responses. His achievements have been published as the corresponding author in prestigious journals such as Nature Cell Biology (2024, 2022, 2019, 2017), Molecular Cell (2022, 2021, 2020, 2014), Cell Host & Microbe, Genes & Development, PLoS Biology, Science Advances, and Journal of Hepatology.
Biography:
Professor, Zhejiang University (2013–present)
Assistant Research Professor, University of California, San Francisco (2011–2013)
Postdoctoral Fellow, University of California, San Francisco (2004–2010)
PhD, Shanghai Institute of Biochemistry and Cell Biology (2003)