Date and time: June 7, 15:30–16:30
Venue: Auditorium, L Building
Host: Chen Jia
Abstract:
APOBEC enzymes are single-stranded DNA cytosine-to-uracil (C-to-U) deaminases. APOBEC mutagenesis has emerged as the second largest source of mutation in cancer. It impacts 70% of all cancer types and is the dominant mutagen in large numbers of bladder, breast, cervical, head/neck, and lung tumors. APOBEC mutagenesis is defined by signature base substitution mutations (C-to-T and C-to-G mutations) in 5’-TCA and 5’-TCT motifs, but its impact is much broader with many C-to-U deamination events leading to DNA breakage, insertion-deletion mutations, and larger-scale chromosomal aberrations. APOBEC also associates with detrimental clinical outcomes including drug resistance and metastasis. This seminar will review seminal advances and discuss recent mechanistic studies.
Biography:
2022–present
Chair of the Biochemistry and Structural Biology Department, University of Texas Health San Antonio
2015–present
Investigator, Howard Hughes Medical Institute (HHMI)
2013–2022
Professor, University of Minnesota Twin Cities
2008–2013
Associate Professor, University of Minnesota Twin Cities
2003–2008
Assistant Professor, University of Minnesota Twin Cities