The baculovirus expression vector system (BEVS) is widely utilized in laboratories and industry for delivering transgenes into insect cells. In addition, baculovirus has also emerged as a gene delivery vector in mammalian cells. Due to its large packaging capacity and its non-replicative and non-integrative nature in mammals, baculovirus has been proposed as a promising gene therapy vect...

Hepatitis B virus (HBV) infection remains a severe global public health issue, with China bearing one of the highest burdens of HBV infection worldwide. It is estimated that over 80 million people in China are currently HBV carriers, with approximately 30 million cases diagnosed as chronic hepatitis B. The surface antigen of the HBV, known as HBsAg, is a critical protein responsible for the invasi...

Recently, the Laboratory of Structural Biochemistry at SIAIS, led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article entitled “Class I histone deacetylase complex: structure and functional correlates” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a 3.2 Å re...

Recently, a group led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao of the laboratory of structure biochemistry at SIAIS, published a paper entitled “Structure of the NuA4 histone acetyltransferase complex” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a near-atomic resolution structure of the NuA4 co...

Recently, Assistant Professor Liu Jia’s group at SIAIS along with his collaborator, Professor Qu Jieming at Ruijin Hospital and the Institutes of Respiratory Diseases of Shanghai Jiao Tong University designed a novel surfaceome CRISPR library and identified OLFML3 as a novel host factor of rhinovirus (RV). They found that OLFML3 could promote RV infection by antagonizing type I interferon (IFN) s...

On February 11, 2021, a research article entitled "Mediator structure and conformation change" was published in Molecular Cell. This report, based on a joint effort of the Lab of Structure Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and collaborators from Stanford describes, for the first time, the cryo-EM structure of the entire Mediator at a near...

On December 18th, SIAIS held the fourth Meeting of the 1st SIAIS Academic Committee in the ShanghaiTech Conference Center. Thirteen SIAIS Academic Committee members, composed of distinguished experts in the field of biomedical research, and thirty representatives of SIAIS faculty attended the meeting.  The meeting was hosted by Rao Zihe, Distinguished Adjunct Professor of SIAIS and Membe...

On August 26th, 2020, a team led by SIAIS Distinguished Adjunct Professor Lin Haifan published new findings in PNAS in an article entitled “PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism”. These findings reveal a new function and action mechanism of PIWI proteins in oncogenesis, guiding the identification of PIWI inhibitors to cure cancer.   Precision m...

On November 3rd, 2020, a team led by SIAIS Distinguished Adjunct Professor Fan Guoping and Research Associate Professor Zhu Xianmin published new findings in the Springer Nature Group Journal Oncogene with the title of “Single-cell RNA sequencing reveals the heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations”. This work is ...

On October 30, 2020, a research article entitled “Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC” was published in Science Advances by a joint research team led by Prof. Rao Zihe, a Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS). This work reported four high-resolution cryo-electron microscopy structure...

On the afternoon of November 2nd, the Portrait Unveiling Ceremony for Richard A. Lerner, Distinguished Adjunct Professor and the Founding Director of SIAIS, was held in the Y Building. Some distinguished guests together unveiled the portrait. Vice Director of SIAIS, Yang Haitao hosted the ceremony, and other attendees included Raymond Stevens, the Founding Director of iHuman Institute, Liu Zhijie,...

Professor Katsuhiko Mikoshiba from the School of Life Science and Technology (SLST) and SIAIS, in collaboration with Professor Makoto Tsuda’s group in Kyushu University, have published research findings in Nature Neuroscience describing a novel type of astrocyte involved in pain regulation: Noradrenergic stimulation aggravates pain through the novel astrocytes, opposite to the classical...

Since developed in 1980s by Prof. Richard Lerner and Prof. Gregory Winter, 2018 Nobel Laureate in Chemistry, combinatorial antibody library technology has been applied in biomedical development and basic science research, etc. Prof. Richard Lerner extended the application of combinatorial antibody to many fields, such as enzyme catalysis, receptor activation and cell fate regulators...

 Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin Nägerl’s group unraveled the morphological mystery of astrocytes.  Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...