Since developed in 1980s by Prof. Richard Lerner and Prof. Gregory Winter, 2018 Nobel Laureate in Chemistry, combinatorial antibody library technology has been applied in biomedical development and basic science research, etc. Prof. Richard Lerner extended the application of combinatorial antibody to many fields, such as enzyme catalysis, receptor activation and cell fate regulators...

 Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin Nägerl’s group unraveled the morphological mystery of astrocytes.  Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...

At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...

Recently, Angewandte Chemie International Edition published a collaborative study led by Professors Richard A. Lerner and Yang Guang from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, entitled “A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries”. This paper has been highlighted as Very Important Paper (Top 5%...

The 3C protease has long been the focus of enterovirus antiviral development. Nevertheless, although anti-enterovirus drugs have a potentially enormous global market, the nucleophilic active site of 3C has frustrated previous drug discovery efforts. Recently, a team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from the Laboratory of Antibody Structure at the Shanghai Institute for ...

On May 8, 2020, the Founding Ceremony was held for the Anti-Tuberculosis (TB) Structure Center (A-TB Center) of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University. The ceremony was followed by the First Academic Symposium of the A-TB Center at SIAIS. President Jiang Mianheng and Professor Rao Zihe at SIAIS, Member of the Chinese Academy of Sciences (CAS), joi...

A research group led by Prof. Katsuhiko Mikoshiba from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University proposes a novel and simple method for creating a stable cytoplasmic antibody, termed STAND, which can be correctly folded and stably expressed in the cytoplasm of the cells. Without the need for complicated amino acid substitutions, it successfully conve...

At 2:00 AM (Beijing Time) on 24th April, a research article titled “Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol” as reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), was published via First Release in Science. This work, for...

Recently, Research Associate Professors Liu Jia, from Lab of Macromolecular Drug Delivery and Ma Peixiang,from Lab of Phenotypic Screening at SIAIS, ShanghaiTech University, reported the first anti-CRISPR peptides. These peptides are derived from the periplasmic domain of the major coat protein G8P (G8PPD) of inoviridae bacteriophages and can allosterically inactivate...

On April 10, 2020, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Research Professor at Tsinghua University, published their research findings in Sc...

Recently, professors Rao Zihe and Yang Haitao at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University, together with their collaborators, have determined the high-resolution crystal structure of main protease (Mpro) from COVID-19 virus and identified drugs that may have promise against COVID-19. Invited by ...

Researchers from SIAIS of ShanghaiTech have been engaged in the race against COVID-19 since the epidemic broke out in January 2020. To accelerate the research work of specific drugs, a symposium on COVID-19 research work was held at SIAIS on March 24. The symposium was hosted by Dr. Jiang Ge, the Executive Director of SIAIS, Vice Provost of ShanghaiTech. Attendees included Dr. Yin Jie, Vice P...

Recently, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Associate Professor at Tsinghua University, reported a 2.9 Å cryo-EM structure of the RNA-d...

On January 26th, professors Rao Zihe and Yang Haitao’s research team at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University determined the high-resolution crystal structure of SARS-CoV-2 3CL hydrolase (Mpro), the only public-domain 3D structure from SARS-CoV-2 currently. The structure data can be downloaded at PDB (Protein Data B...