In November, SIAIS Professor Katsuhiko Mikoshiba and Research Associate Professor Kozo Hamada of Cell Calcium Signaling laboratory published a review paper entitled ‘IP3 Receptor Plasticity Underlying Diverse Functions’ in Annual Review of Physiology. The paper reviews recent progress on the IP3 receptor structure and function, and the authors propose a new concept of how protein plast...

SIAIS Principal Investigator Dr. Rao Zihe and his team recently unveiled the 3-dimensional structure of the African swine fever (ASF) virus, a giant and complex virus which causes a contagious and lethal swine disease all over the world. The study, entitled ‘Architecture of African swine fever virus and implications for viral assembly,’ was published in Science on Oct 17th.  Since...

The Sino-German Symposium Shanghai 2019 was held successfully from September 17th to 21st 2019 at ShanghaiTech University. The symposium was jointly organized by ShanghaiTech University and German Cancer Research Center (DKFZ), with the support from Das Chinesisch-Deutsche Zentrum für Wissenschaftsförderung (CDZ, the Sino-German Center for Research Promotion). Under the theme of ‘Frontiers in tr...

On September 17, a delegation from Leiden University in Netherland visited Shanghai Institute for Advanced Immunochemical Studies (SIAIS). The delegation, led by Professor Peter ten Dijke and Professor Jacques Neefjes, met with the Executive Director of SIAIS, Jiang Ge at the Y Building. Associate Professor David Baker and Assistant Professor Baoxu Pang from Leiden University Medical Center also a...

The first Symposium on Frontier in PROTAC Drug Discovery and Development was held on May 16th by the Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at the Conference Center of ShanghaiTech University. This symposium received wide attention and enthusiastic response from the more than 600 attendees from enterprises and academia in China and abroad. Notably, more than half of the att...

On May 2nd, Advanced Science published a collaborative study from Drs. Liu Jia, Jiang Biao Laboratories of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Dr. Jiang Xianxing from the School of Pharmaceutical Science at Sun Yat-Sen University, entitled “Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction”. Their study devel...

A team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from ShanghaiTech’s SIAIS and Dr. Lu Lu and Dr. Jiang Shibo from Fudan University’s School of Basic Medical Sciences have developed a pan-coronavirus (pan-CoV) fusion inhibitor EK1. EK1 targets the HR1 domains of various human coronavirus (HCoV) spike (S) proteins to prevent the host-HCoV membrane fusion process and inhibits the host...

Human induced pluripotent stem cells (hiPSCs) are embryonic-like stem cells derived from adult somatic cells by a reprogramming process. They have a number of potential applications in stem cell biology and regenerative medicine, including precision medicine. However, their potential clinical application is hampered by the low efficiency, high costs, and heavy workload of the reprogramming process...

The 5th ShanghaiTech-SIAIS Bioforum was successfully held November 13th to 16th at ShanghaiTech University, with the theme of “Advances in Integrative Biology of Cellular Processes.” The main topic discussed was breakthrough Technological Advances in Protein Research (Cryo-EM, Optogenetics, DNA-encoded Chemical Libraries). Over 500 attendees from universities, research institutions and corp...

On October 25th, ShanghaiTech Distinguished Professor-in-Residence Rao Zihe and his team’s research on “An electron transfer path connects subunits of a mycobacterial respiratory supercomplex” was published online in Science journal.On the strength of cryo-electron microscopy (cryo-EM) with high resolution (3.5 Å) structure of mycobacterial respiratory supercomplex, the team revealed a new...

Recently, SIAIS’s Stem Cell Biology Lab has revealed a new mechanism of Wnt/β-catenin signaling pathway activation in triple-negative breast cancer, which was published as a cover story in Journal of Molecular Cell Biology with the title "MiR-221/222 activate the Wnt/beta-catenin signaling to promote triple negative breast cancer."Breast cancer is the most invasive type of cancer ...

Research Associate Professor Liu Jia from SIAIS Professor Jiang Biao’s ADC Chemistry Lab has completed editing the 1867 volume of Methods in Molecular Biology (MiMB) with titled “Zinc Finger Proteins: Methods and Protocols,” now available from Springer, Amazon and other booksellers.The MiMB series, providing methods and protocols in molecular biology, was founded by editor John Walker in 1...

The 2018 Nobel Prize in Chemistry was announced on October 3rd.  The winners for this year are Frances H. Arnold (USA), George P. Smith (USA) and Sir Gregory P. Winter (UK). Frances Arnold shares half of the prize for her research "for the directed evolution of enzymes." George Smith and Gregory Winter share the other half of the prize for their research "for the phage display ...

A research collaboration between the laboratories of Yang Guang and Richard Lerner of SIAIS in ShanghaiTech University and the laboratory of Xu Tianle in Shanghai Jiao Tong University School of Medicine has led to an article published in the Proceedings of the National Academy of Sciences of the United States of America on July 25th. The article, “Selection of an ASIC1a-blocking combina...