On 29 April 2020, a research work carried out collaboratively by Professors Qi Hai and Zhong Yi from Tsinghua University and Professor Hu Ji from the School of Life Science and Technology (SLST) of ShanghaiTech University was published in Nature entitled “Brain control of humoral immune responses amenable to behavioural modulation”. The researchers identify a specific brain-spleen neur...

Recently, different research teams led by Professor Sun Bo from SLST and Professor Xi Xu-Guang from French National Centre for Scientific Research (CNRS) have collaboratively published a research article entitled “Human RPA activates BLM's bidirectional DNA unwinding from a nick” in the journal eLife, revealing a novel unwinding model of a DNA-repair-i...

Groups of professors Liu Ji-Long，Zhuang Min, and Lu Pengfei from the School of Life Science and Technology (SLST) at ShanghaiTech University have jointly developed a new method CRUIS, or CRISPR-based RNA-United Interacting System, for capturing RNA-protein interactions on specific RNAs. It is a hybrid of two molecular machineries, CRISPR-based RNA-targeting Cas nuclease (dCas13a) and a proximity-...

A team of scientists led by Professor Lu Pengfei from SLST has unexpectedly identified that the traditional tight junction protein Occludin does not act as a barrier in epithelial tissue as expected. Instead, Occludin plays a vital role in the regulation of extremely basic and important protein production and secretion. On February 13th, 2020, the work from Lu's lab was publishe...

iHuman Institute and SLST Professor Shui Wenqing’s group published a review in Current Opinion in Biotechnology in October 2019, “Systematic mapping of protein-metabolite interactions with mass spectrometry-based techniques”. This review presents a comprehensive overview of chemical proteomics techniques developed for probing protein-metabolite interactions in the cell. Shui Wenqing’...

A research group led by iHuman Institute and SLST Assistant Professor Zhao Suwen, working with Professor Wang Ming-Wei from Shanghai Institute of Materia Medica/The National Center for Drug Screening/Fudan University and Professor Babu Madan from MRC Laboratory of Molecular Biology, recently discovered a common activation pathway in class A GPCRs. Their study, “Common activation mechanism of clas...

Recently, a collaborative study led by Assistant Professor Zhao Suwen and Assistant Professor Zhong Guisheng at iHuman Institute and School of Life Science and Technology, and Research Associate Professor Wu Dong at iHuman Institute reported two crystal structures of human α2A adrenergic receptor (α2AAR) in complex with a partial agonist and an antagonist, and discovered key non-conserved r...

A committee of twelve internationally renowned scientists carried out the first quinquennial review (QQR) on the development and progress of the School of Life Science and Technology (SLST) from 15th-18th November 2019.The committee was warmly welcomed by University Council Chairman Li Ruxin. Vice President and Provost Yin Jie introduced the brief history of ShanghaiTech University since its estab...

On November 10-14th, the 2019 ShanghaiTech BioForum was successfully held at ShanghaiTech University. For the first time, the BioForum was jointly organized by the three life science institutions of ShanghaiTech University - School of Life Science and Technology (SLST), Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and iHuman Institute (iHuman), which compose the “ShanghaiTech Li...

A tumor immunogenicity score (TIGS), a novel cancer immunotherapy biomarker, was proposed by a research team from the School of Life Science and Technology (SLST) led by Assistant Professor Liu Xuesong. The study describing TIGS was published online in the journal eLife on November 26th. This tumor immunogenicity-based biomarker could guide the treatment to transform some immunotherapy n...

A study published in Genome Biology systematically compares a panel of BEs for the first time and BEable-GPS is the first database to profile the accessibility of BEs to target pathogenic SNVs. BEable-GPS and its embedded toolsets will provide researchers a great resource for their experimental designs to model or correct disease-related mutations.This study results from a collaboration betwe...

Research teams led by Professor Sun Bo from SLST and Professor Shen Bin from Nanjing Medical University have completed a high-resolution quantitative map of Cas9/sgRNA/DNA interactions (Figure 1). On November 13, 2019, their study was published as a research article entitled, “The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation," in the journal...

On August 29th, 2019, a study led by a collaboration between ShanghaiTech Adjunct Professor Rao Zihe and SLST Adjunct Professor and CAS Institute of Biophysics Hu Junjie’s group was published online in Nature Communications. In the research article, “Mycobacterial dynamin-like protein IniA mediates membrane fission,” they reported the crystal structure of IniA, an isoniazid inducible protein, w...

When the undergraduate Class of 2019 crosses the stage to receive their diplomas this month, they represent the best ShanghaiTech has to offer. The paths they took converged for four years on campus together, and now they prepare to head off in different directions. School of Life Science and Technology graduating senior Zhang Yuxi’s college experience didn’t start out so well. She felt dis...