Genome editing is a type of genetic engineering, which utilizes programmable nucleases such as the Cas9 nuclease to achieve desired base insertion, deletion or substitutions in the genome of living organisms. Directed by guide RNA (gRNA), Cas9 nuclease can generate DNA double strand breaks (DSBs) at targeted genomic sites. Subsequent resolving of the generated DSB through non-homologous end joinin...

A team of scientists led by Dr. Huang Xingxu at the School of Life Science and Technology at ShanghaiTech and Dr. Liu Jiang at the Beijing Institute of Genomics, Chinese Academy of Sciences, has successfully described the chromatin interaction map of mice with male and female gametes and early embryos at different developmental stages and revealed global chromatin architecture reprogramming during...

ShanghaiTech’s first NanoTemper Forum of Tumor Immunotherapy attracted nearly 200 attendees from academia, clinical practice and industry. The forum was jointly sponsored by the Shanghai Association for Science and Technology, Shanghai Society of Biophysics and ShanghaiTech’s School of Life Science and Technology.An opening ceremony was held on June 27 with a welcome from vice president and prov...

Recently, Dr. Wei L. Shen’s group from ShanghaiTech University has published a research article in Proceedings of the National Academy of Sciences titled with “A hypothalamic circuit that controls body temperature.” They have elucidated a neural mechanism responsible for heat defensive behavior.Thermal homeostasis is essential for survival in mammals. Significant deviation of body temperat...