CRISPR-Sirius, a sensitive and bright imaging system, has been developed by research groups led by Dr. Ma Hanhui at ShanghaiTech University and Dr. Thoru Pederson at the University of Massachusetts Medical School. Their study was recently published in Nature Methods, a prestigious scientific journal.CRISPR-Sirius makes it possible to detect low-copy repeats distributed in the intergenic and genic ...

A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang from ShanghaiTech’s School of Life Science and Technology and Dr. Li Yang from the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel base editors (BEs) using a spectrum of cytidine deaminases from different species, including human APOBEC3A (hA3A). Their work, ...

Cell and cellular organelles communication are often controlled by the membrane protein interaction. Despite the many existing methods to detect protein-protein interactions (PPIs), there are still challenges in detecting membrane PPIs. Transient and weak PPIs are mostly associated with membrane receptor-mediated signaling pathways. Mass spectrometry-based membrane protein interaction studies have...

A recent international research collaboration has shed new light on DNA replication. The collaboration, led by Professor Bo Sun from the School of Life Science and Technology at ShanghaiTech University and Professor Michelle D. Wang from the Howard Hughes Medical Institute (HHMI) and Cornell University, revealed a new replication recovery pathway. Their paper, “Helicase Promotes Replication Re-in...

The prognosis of late stage cancer patients after traditional cancer treatments such as radiation, surgery and chemotherapy is always poor. Immunotherapy with antibodies targeting immune checkpoints represents a major breakthrough in cancer treatment. Some cases of patients previously consideredincurable are now able to be cured through immunotherapy. However, only a fraction of patients show...

Lin Haifan, Founding Dean of School of Life Science and Technology (SLST) of ShanghaiTech, Yale University Professor of Cell Biology and Reproductive Sciences and Director of the Yale Stem Cell Center, was among 213 academics newly elected as members of the American Academy of Arts and Sciences (AAAS), which celebrates excellence in a wide range of disciplines.Professor Lin’s work focuses on the ...

An international effort within the immunology research community resulted in the first genome-wide CRISPR screen focused on the molecular mechanism of T cell function regulation. A group of scientists led by Dr. Haopeng Wang of ShanghaiTech’s School of Life Science and Technology, along with Dr. Arthur Weiss at UCSF and Dr. Lai Wei of the Zhongshan Ophthalmic Center at Sun Yat-sen University...

A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang of the School of Life Science and Technology at ShanghaiTech University, along with Dr Li Yang of the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel CRISPR/Cpf1 (Cas12a) bases editors. The paper entitled “Base editing with a Cpf1– cytidine deaminase fusion”...

Nature Neuroscience recently published a study demonstrating that the transcription of multiple genes in the brain can be simultaneously activated using CRISPR–dCas9-activator transgenic mice. This work was performed by researchers in Dr. YANG Hui’s lab at the Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Techn...

A team of scientists led by Dr. Jia Chen in the School of Life Science and Technology at ShanghaiTech University, Dr. Li Yang in the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, and Dr. Bin Shen in the State Key Laboratory of Reproductive Medicine in the Department of Histology and Embryology at Nanjing Medical University has revealed that APOBEC3 induces...

ShanghaiTech’s School of Life Science and Technology (SLST) held the 5th Annual ShanghaiTech BioFrontier Conference -- Frontier of Genetics and Genomics (FoGG2017) on October 20-21st, 2017, in the auditorium of the newly completed L building, the home of SLST.Nearly 300 researchers from leading institutions gathered at the conference to present and discuss cutting-edge progress in a broad sp...

A team led by Assistant Professor Huang Pengyu at ShanghaiTech University’s School of Life Science and Technology, collaborating with Sun Yat-sen Memorial Hospital at Guangzhou, found an important role of IGF-2 in liver regeneration induced by some chronic liver injuries. Their work entitled “Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries” was publis...

Genome editing is a type of genetic engineering, which utilizes programmable nucleases such as the Cas9 nuclease to achieve desired base insertion, deletion or substitutions in the genome of living organisms. Directed by guide RNA (gRNA), Cas9 nuclease can generate DNA double strand breaks (DSBs) at targeted genomic sites. Subsequent resolving of the generated DSB through non-homologous end joinin...

A team of scientists led by Dr. Huang Xingxu at the School of Life Science and Technology at ShanghaiTech and Dr. Liu Jiang at the Beijing Institute of Genomics, Chinese Academy of Sciences, has successfully described the chromatin interaction map of mice with male and female gametes and early embryos at different developmental stages and revealed global chromatin architecture reprogramming during...