Memory is stored in neural networks via changes in synaptic strength mediated by long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B-receptor antagonist blocks high-frequency stimulation (HFS)-induced neocortical LTP, whereas local infusion of CCK induces LTP in the auditory cortex. We identified that entorhinocortical terminals release CCK, which enables neocortical LTP and ...

Relativistic interactions with matter involving heavy high-Z ions provide a unique testing ground for our understanding of quantum electrodynamics and correlation in the non-perturbative regime as well as of elementary atomic processes mediated by ultrafast electromagnetic interactions. For this realm of physics, the future international accelerator Facility for Antiproton and Ion Research (FAIR) ...

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The shift from hypothesis-driven biomedical research to data-driven, AI-led approaches is a hallmark of the current era of rapid advances in AI technologies and growing availability of multi-omics data that characterize cellular states at various molecular levels. Similar to how natural languages describe the physical world, genes can be seen as the "words" of life's genetic language. In...