Cryo-EM Insights into Epigenetic Genome Regulation by Chromatin
The eukaryotic genome is tightly compacted in the nucleus as chromatin, with the nucleosome core particle (NCP) as its basic unit, comprising of ~145 base pairs of DNA wrapped around a histone octamer (two copies each of H2A-H2B and H3-H4). Despite this dense packaging, regulatory processes like transcription, replication, and repair must access DNA, necessitating chromatin remodeling. While chrom...
2025-04-13