Neural mechanisms underlying ketamine’s mode of action
Ketamine, the NMDAR antagonist, has revolutionized depression treatment because of its robust, rapid and sustained antidepressant effects. Recently, it was discovered that ketamine inhibits the NMDAR-dependent burst firing of the brain’s anti-reward center, the lateral habenula (LHb). By silencing the LHb bursts, ketamine can potentially disinhibit the aminergic reward circuits downstream of the...
2024-12-23