My laboratory is interested in epigenetic inheritance and cancer epigenetics. At this seminar, I will present our recent findings related to epigenetic inheritance and cancer epigenetics. Specifically, I will first summarize how nucleosomes, the basic repeat units of chromatin, are reassembled following DNA replication for epigenetic inheritance, and how this process is important to maintain heterochromatin silencing at transposable elements in mammalian genomes. I will then discuss on how onco-histone mutations found in high grade pediatric glioma reprogram epigenome to drive tumorigenesis and how we leverage these insights to identify drug targets for this deadly disease.